ADGRG1 blockade drives astrocyte positioning into the extracellular matrix to reduce scar size
Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Kazuya Yokota, Tetsuya Tamaru, Kazuhiro Hata, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Jun Kishikawa, Kiyoshi Tarukado, Kenichi Kawaguchi, Daijiro Konno, Kinichi Nakashima, Takeshi Maeda, , Yasuharu Nakashima
This study shows that blocking ADGRG1 allows astrocytes to enter the fibrotic matrix, reducing scar size and improving motor recovery after CNS injury.
bioRxiv · Dec 22, 2025 · PreprintNeuroscience