HOT or not: Examining the basis of high-occupancy target regions
Katarzyna Wreczycka, Vedran Franke, Bora Uyar, Ricardo Wurmus, Selman Bulut, Baris Tursun, Altuna Akalin
The paper investigates whether HOT regions are genuine transcription factor binding sites or ChIP-seq artifacts, finding they likely result from technical biases and specific sequence features.
Nucleic Acids Research · May 13, 2019Peer-reviewedGenomics