Baris Tursun

Depletion of the isocitrate dehydrogenase 3 subunit IDHA-1 licenses germ cell-to-neuron direct reprogramming in C. elegans

This study identifies IDHA-1 as a barrier to direct reprogramming of germ cells to neurons in C. elegans, showing metabolic and epigenetic mechanisms that maintain germ cell identity.

The CONDOR pipeline for simultaneous knockdown of multiple genes identifies RBBP-5 as a germ cell reprogramming barrier in C. elegans

The paper introduces CONDOR, a bacterial conjugation-mediated double RNAi technique for high-throughput gene knockdown in C. elegans, identifying RBBP-5 as a barrier to germ cell reprogramming.

HOT or not: Examining the basis of high-occupancy target regions

The paper investigates whether HOT regions are genuine transcription factor binding sites or ChIP-seq artifacts, finding they likely result from technical biases and specific sequence features.

FACT sets a barrier for cell fate reprogramming in C. elegans and Human

The paper identifies FACT as a conserved reprogramming barrier in C. elegans and humans that maintains cell identity by modulating chromatin accessibility.

Determinants of Transcription Initiation Directionality in Metazoans

The paper investigates transcription initiation directionality in metazoans, finding species-specific sequence asymmetry and independent initiation events at promoters and enhancers.

Neuronal Inhibition Of The Autophagy Nucleation Complex Extends Lifespan In Post-Reproductive C. elegans

The paper identifies genes regulating post-reproductive longevity in C. elegans, showing that inhibiting autophagy nucleation extends lifespan and healthspan via neuronal mechanisms.