Non-invasive imaging of gene expression and protein secretion dynamics in living mice: identification of ectopic prothrombin expression as driver of thrombosis in cancer
Jamie P. Nourse, Sergey Tokalov, Shazad Khokhar, Essak Khan, Lina K. Schott, Lisa Hinz, Ludwig Eder, Danielle Arnold-Schild, Johanna Satrapa, Karl Johannes Lackner, Hugo Ten Cate, Hans Christian Probst, Sven Danckwardt
This paper introduces a genetic tagging strategy to non-invasively image secretory protein dynamics in living mice, revealing ectopic prothrombin expression in tumors that contributes to thrombosis.
bioRxiv · Jul 8, 2021 · PreprintGenetics