Author

Sven Danckwardt

University Medical Center of the Johannes Gutenberg University MainzORCID 0000-0002-3176-2265Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Denise Scherzinger· 2 shared Fédérico MariniiD· 2 shared Hans Christian ProbstiD· 2 shared Jamie P. Nourse· 2 shared Karl Johannes LackneriD· 2 shared Andrew D. JohnsoniD· 1 shared Anne BolandiD· 1 shared Ansgar PoetschiD· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenomics

Denise Scherzinger

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Author profile →

5 papers

Recent·Most cited

Genomic Landscape of Thrombosis Recurrence Risk Across Venous Thromboembolism Subtypes

Gaëlle Munsch, Florian Thibord, Ohanna Cavalcanti de Lima Bezerra, Jennifer A. Brody, Astrid van Hylckama Vlieg, Lénaïck Gourhant, Ming‐Huei Chen, Marine Germain, Ilana Caro, Pierre Suchon, Robert Olaso, Kerri L. Wiggins, Noémie Saut, Céline Besse, Louisa Goumidi, , David‐Alexandre Trégouët

The paper identifies genetic loci and proteins associated with venous thromboembolism recurrence risk using GWAS and subgroup analyses across different thrombotic subtypes.

medRxiv · Dec 2, 2024 · PreprintGenetic & Genomic Medicine

Non-invasive imaging of gene expression and protein secretion dynamics in living mice: identification of ectopic prothrombin expression as driver of thrombosis in cancer

Jamie P. Nourse, Sergey Tokalov, Shazad Khokhar, Essak Khan, Lina K. Schott, Lisa Hinz, Ludwig Eder, Danielle Arnold-Schild, Johanna Satrapa, Karl Johannes Lackner, Hugo Ten Cate, Hans Christian Probst, Sven Danckwardt

This paper introduces a genetic tagging strategy to non-invasively image secretory protein dynamics in living mice, revealing ectopic prothrombin expression in tumors that contributes to thrombosis.

bioRxiv · Jul 8, 2021 · PreprintGenetics

A novel rationale for targeting FXI: Insights from the hemostatic miRNA targetome for emerging anticoagulant strategies

Jamie P. Nourse, Sven Danckwardt

The paper introduces a novel rationale for targeting factor XI using miRNA mimics to develop anticoagulants that avoid disrupting hemostasis.

Pharmacology & Therapeutics · Sep 6, 2020Peer-reviewedMolecular Biology

TREND-DB - A Transcriptome-wide Atlas of the Dynamic Landscape of Alternative Polyadenylation

Fédérico Marini, Denise Scherzinger, Sven Danckwardt

TREND-DB catalogs the dynamic landscape of alternative polyadenylation by analyzing transcriptome changes after depleting >170 proteins involved in gene regulation and epigenetics.

Nucleic Acids Research · Aug 25, 2020Peer-reviewedGenomics

PCF11 connects alternative polyadenylation to formation and spontaneous regression of neuroblastoma

Anton Ogorodnikov, Michal Levin, Surendra Mohan Tattikota, Sergey V. Tokalov, Mainul Hoque, Denise Scherzinger, Fédérico Marini, Ansgar Poetsch, Harald Binder, Stephan Macher-Göppinger, Hans Christian Probst, Bin Tian, Michael Schaefer, Karl Johannes Lackner, Frank Westermann, Sven Danckwardt

The paper identifies PCF11 as a critical regulator of alternative polyadenylation in neuroblastoma, linking it to cell fate reprogramming and spontaneous tumor regression.

Nature Communications · Dec 10, 2018Peer-reviewedGenomics