Author

Karl Johannes Lackner

University Medical Center of the Johannes Gutenberg University MainzORCID 0000-0002-1985-7931Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:GWAS / association mapping· 1 Assay:imaging· 1

Frequent Co-Authors

Hans Christian ProbstiD· 2 shared Sven DanckwardtiD· 2 shared Alessandra RossiniiD· 1 shared Alexander TeumeriD· 1 shared André Gerardus UitterlindeniD· 1 shared Anna F. DominiczakiD· 1 shared Ansgar PoetschiD· 1 shared Anton Ogorodnikov· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

Hans Christian ProbstORCID

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3 papers

Recent·Most cited

Non-invasive imaging of gene expression and protein secretion dynamics in living mice: identification of ectopic prothrombin expression as driver of thrombosis in cancer

Jamie P. Nourse, Sergey Tokalov, Shazad Khokhar, Essak Khan, Lina K. Schott, Lisa Hinz, Ludwig Eder, Danielle Arnold-Schild, Johanna Satrapa, Karl Johannes Lackner, Hugo Ten Cate, Hans Christian Probst, Sven Danckwardt

This paper introduces a genetic tagging strategy to non-invasively image secretory protein dynamics in living mice, revealing ectopic prothrombin expression in tumors that contributes to thrombosis.

bioRxiv · Jul 8, 2021 · PreprintGenetics

KCND3 is a novel susceptibility locus for early repolarization

Alexander Teumer, Teresa Trenkwalder, Thorsten Kessler, Yalda Jamshidi, Marten E. van den Berg, Bernhard M. Kaess, Christopher P. Nelson, Rachel Bastiaenen, Marzia De Bortoli, Alessandra Rossini, Isabel Deisenhofer, Klaus J. Stark, Solmaz Assa, Peter S. Braund, Claudia Cabrera, , Wibke Reinhard

This study identifies a genome-wide significant association between a variant in the KCND3 gene and early repolarization pattern on ECG, suggesting a genetic basis for this trait.

bioRxiv · Jun 18, 2019 · PreprintGenetics

PCF11 connects alternative polyadenylation to formation and spontaneous regression of neuroblastoma

Anton Ogorodnikov, Michal Levin, Surendra Mohan Tattikota, Sergey V. Tokalov, Mainul Hoque, Denise Scherzinger, Fédérico Marini, Ansgar Poetsch, Harald Binder, Stephan Macher-Göppinger, Hans Christian Probst, Bin Tian, Michael Schaefer, Karl Johannes Lackner, Frank Westermann, Sven Danckwardt

The paper identifies PCF11 as a critical regulator of alternative polyadenylation in neuroblastoma, linking it to cell fate reprogramming and spontaneous tumor regression.

Nature Communications · Dec 10, 2018Peer-reviewedGenomics