Loss of estrogen unleashing neuro-inflammation increases the risk of Alzheimer's disease in women
Fuhai Li, Inez Y. Oh, Sayantan Kumar, Abdallah M. Eteleeb, Aditi Gupta, William Buchser, Chengjie Xiong, Sessions F. Cole, Eric McDade, Celeste M M. Karch, Oscar Harari, Philip Payne, Carlos Cruchaga
This study identifies estrogen's role in suppressing neuro-inflammation and links its loss to increased Alzheimer's disease risk in women through systems pharmacology and signaling network analysis.
bioRxiv · Sep 19, 2022 · PreprintNeuroscience