Inez Y. Oh

Examining heterogeneity in dementia using data-driven unsupervised clustering of cognitive profiles

This study uses unsupervised clustering on longitudinal cognitive data to identify subtypes of dementia, finding that mild dementia subtypes are more heterogeneous in progression.

Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors

The paper examines how different pathogenic variants in the CRX gene affect cis-regulatory elements in photoreceptors, showing overlapping enhancer effects and distinct silencer impacts.

Leveraging GPT-4 for Identifying Cancer Phenotypes in Electronic Health Records: A Performance Comparison between GPT-4, GPT-3.5-turbo, Flan-T5 and spaCy's Rule-based & Machine Learning-based methods

This paper compares GPT-4, GPT-3.5-turbo, Flan-T5, and spaCy-based methods for identifying cancer phenotypes from EHRs, finding GPT-4 achieves higher precision, recall, and F1 scores.

Loss of estrogen unleashing neuro-inflammation increases the risk of Alzheimer's disease in women

This study identifies estrogen's role in suppressing neuro-inflammation and links its loss to increased Alzheimer's disease risk in women through systems pharmacology and signaling network analysis.

An enhancer:involucrin regulatory module impacts human skin barrier adaptation out-of-Africa and modifies atopic dermatitis risk

The paper identifies an enhancer-IVL regulatory module that evolved in humans and is associated with skin barrier adaptation and atopic dermatitis risk.