William Buchser

BioMedGraphica: An All-in-One Platform for Joint Textual Biomedical Prior Knowledge and Numeric Graph Generation

BioMedGraphica integrates biomedical knowledge into a unified graph and introduces a Textual-Numeric Graph structure for multi-omics analysis.

Intellectual disability risk gene RFX4 regulates cortical neurogenesis by restraining neuronal differentiation

This study identifies RFX4's role in cortical development by showing it restrains neurogenesis and regulates synaptic gene expression, with distinct effects from haploinsufficiency.

Pathogenic Morphological Signatures of Perturbations in Mitochondrial-Related Genes Revealed by Pooled Imaging Assay

The paper identifies mitochondrial-related genes critical for morphology using a pooled imaging assay and reveals pathogenic variants associated with mitochondrial aggregation.

OmniCellAgent: An AI Scientist for Omic-Driven Scientific Discovery

OmniCellAgent autonomously retrieves and analyzes scRNA-seq datasets to generate structured reports and hypotheses across disease settings.

SARM1 is an essential component of neuronal Parthanatos

This study shows SARM1 is essential for neuronal Parthanatos, a cell death pathway triggered by DNA damage and linked to neurodegenerative diseases.

Subtle Cellular Phenotypes Inform Pathological and Benign Genetic Mutants in the Iduronidase-2 Sulfatase Gene

This study uses genome-engineered cells with IDS mutations to identify subtle lysosomal and membrane phenotypes that correlate with genetic variants in the IDS gene, improving the assessment of variant pathogenicity.

Classification of iPSC-Derived Cultures Using Convolutional Neural Networks to Identify Single Differentiated Neurons for Isolation or Measurement

The paper presents a CNN-based model for identifying single neurons in iPSC-derived cultures with high accuracy, and demonstrates its applicability to other cell types.

Biophysical Simulation Enables Multi-Scale Segmentation and Atlas Mapping for Top-Down Spatial Omics of the Nervous System

SiDoLa-NS uses synthetic images and multi-scale CNNs to achieve high-precision segmentation of nuclei and tissue structures in nervous system samples.

Loss of estrogen unleashing neuro-inflammation increases the risk of Alzheimer's disease in women

This study identifies estrogen's role in suppressing neuro-inflammation and links its loss to increased Alzheimer's disease risk in women through systems pharmacology and signaling network analysis.

Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

This paper introduces SCALES, a method that extracts hierarchical protein interaction networks from bacterial proteome variation patterns, revealing new genetic factors in Pseudomonas aeruginosa motility.

Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease

Mitochondrial Phenotypes Distinguish Pathogenic MFN2 Mutations by Pooled Functional Genomics Screen

The paper introduces Raft-Seq, a functional genomics platform that distinguishes pathogenic MFN2 mutations using high-content imaging, machine learning, and microraft isolation.

Modulating Intra-Nuclear LC3 with Small Molecules Rescues Cells from a Docetaxel-Induced Phenotype

The paper identifies small molecules that modulate nuclear LC3, rescuing cells from docetaxel-induced nuclear stress.

Integrative omics data analysis uncovers biomarker genes and potential candidate drugs for G3 medulloblastoma

This study identifies biomarker genes and potential drugs for G3 medulloblastoma using integrative omics analysis of gene expression, methylation, and copy number data.