A Cross-scale Causal Mapping Framework Pinpoints Macrophage Orchestrators of Balanced Arterial Development
Jonghyeuk Han, Dasom Kong, Erica L. Schwarz, Felipe Takaesu, Seunguk Lee, Chae-lin Kim, Evan Yang, Minseon Park, Eunha Kim, Wook Kim, Abhay B. Ramachandra, Edward P. Manning, Jay D. Humphrey, Hyun-Ji Park, Michael E. Davis
This study introduces CausaLink, a cross-scale causal mapping framework that identifies Mgl2 macrophages as key regulators of balanced arterial development using single-cell transcriptomics and organoid validation.
bioRxiv · Oct 8, 2025 · PreprintBioengineering