Michael E. Davis

The Fontan EV Score: A Circulating Extracellular Vesicle-Based Risk Stratification Tool for Fontan-Associated Liver Disease

This paper develops the Fontan EV Score, a non-invasive biomarker using circulating extracellular vesicles to predict Fontan-associated liver disease severity, outperforming existing serological indices.

Serum Proteomic Profiling Implicates a Dysregulated Neurohormonal-Inflammatory Axis in Post-Fontan Tachycardia

This study uses serum proteomics and machine learning to identify a seven-protein panel predictive of post-Fontan tachycardia, implicating a dysregulated neurohormonal-inflammatory axis.

Machine Learning Identifies Distinct Treg-Mediated Remodeling in HFpEF Hearts Treated with Neonatal Mesenchymal Stem Cells and Their Secretome

This study uses machine learning to identify Treg-mediated mechanisms by which nMSCs and their secretome improve diastolic function in HFpEF.

A Cross-scale Causal Mapping Framework Pinpoints Macrophage Orchestrators of Balanced Arterial Development

This study introduces CausaLink, a cross-scale causal mapping framework that identifies Mgl2 macrophages as key regulators of balanced arterial development using single-cell transcriptomics and organoid validation.

Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart

This study identifies SLC25A1 as a dosage-dependent regulator of metabolic reprogramming and heart development, linking mitochondrial function to cardiac morphogenesis and congenital heart disease.

A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells

This study identifies a non-canonical JAG1 signal to JAK2 pathway that mediates osteoblast commitment in cranial neural crest cells, independent of the canonical NOTCH pathway.