Abhay B. Ramachandra

The paper develops a multimodal model to predict biological age using vascular microstructure and biomechanical parameters in mice, achieving high predictive accuracy.

The paper presents data on normal postnatal development of pulmonary arteries in mice and develops a computational model to simulate responses to hemodynamic perturbations.

This study quantifies biological cardiopulmonary aging in mice by integrating biomechanics and single-cell transcriptomics, revealing non-linear aging patterns and cell-type-specific gene expression changes.

The paper investigates age-related changes in proximal pulmonary artery mechanics in mouse models, finding increased stiffness and collagen reorientation linked to aging biomarkers and cellular senescence.

This study introduces CausaLink, a cross-scale causal mapping framework that identifies Mgl2 macrophages as key regulators of balanced arterial development using single-cell transcriptomics and organoid validation.

This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.