The rich get richer: synaptic remodeling between climbing fibers and Purkinje cells in the developing cerebellum begins with positive feedback addition of synapses.
Alyssa Michelle Wilson, Richard Lee Schalek, Adi Suissa‐Peleg, Thouis R. Jones, Seymour Knowles-Barley, Hanspeter Pfister, Jeff William Lichtman
The paper shows that during cerebellar development, climbing fibers add synapses to a subset of Purkinje cells through positive feedback, without pruning other connections, and that this process is economical due to matching axon and Purkinje cell numbers.
bioRxiv · May 3, 2019 · PreprintNeuroscience