Ancestral resurrection reveals mechanisms of kinase regulatory evolution
Dajun Sang, Sudarshan Pinglay, Sezen Vatansever, Hua Jane Lou, Benjamin Turk, Zeynep H. Gümüş, Liam J. Holt
The paper uses ancestral resurrection to show that changes in the β3-C loop and gatekeeper residue in ERK kinases drove the evolution of lower intrinsic autophosphorylation.
bioRxiv · May 25, 2018 · PreprintEvolutionary Biology