Dysregulated actin dynamics and cofilin correlate with TDP-43 pathology in sporadic amyotrophic lateral sclerosis
Cyril Jones Jagaraj, Prachi M. Mehta, Sonam Parakh, Sina Shadfar, Shafi Jamali, Alexandra K. Suchowerska, Jessica Sultana, Thomas Fath, Julie D. Atkin
This study shows that dysregulated actin dynamics and cofilin phosphorylation are linked to TDP-43 pathology in sporadic ALS, suggesting potential therapeutic targets.
bioRxiv · Aug 28, 2023 · PreprintNeuroscience