Author

Prachi M. Mehta

Macquarie UniversityORCID 0000-0003-2067-3774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adam K. WalkeriD· 2 shared Albert LeeiD· 2 shared Amanda L. WrightiD· 2 shared Britt A. BerningiD· 2 shared Juliana VenturatoiD· 2 shared Julie D. AtkiniD· 2 shared Marco MorschiD· 2 shared Rebecca San GiliD· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Adam K. WalkerORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 28, 2023

Dysregulated actin dynamics and cofilin correlate with TDP-43 pathology in sporadic amyotrophic lateral sclerosis

Cyril Jones Jagaraj, Prachi M. Mehta, Sonam Parakh…·Julie D. Atkin

This study shows that dysregulated actin dynamics and cofilin phosphorylation are linked to TDP-43 pathology in sporadic ALS, suggesting potential therapeutic targets.

DOI 10.1101/2023.08.28.555209

humanmouse

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NeurosciencebioRxivPreprintJun 21, 2023

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated disease

Rebecca San Gil, Dana Pascovici, Juliana Venturato…·Adam K. Walker

This study identifies a transient protein folding response in early TDP-43 disease that reduces aggregation, with DNAJB5 as a protective factor, and shows proteomic similarities between mouse and human TDP-43 proteinopathies.

1 citation

mouseproteomics

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NeuroscienceEuropean Journal of NeurosciencePeer-reviewedAug 13, 2021

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis

Amanda L. Wright, Paul A. Della Gatta, Sheng Le…·Adam K. Walker

This study shows riluzole does not improve disease outcomes in a mouse model of ALS with cytoplasmic TDP-43 pathology.

35 citations

mouseproteomics

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