Increased Synapse Elimination by Inflammatory Cells Contributes to Long-lasting Post-Stroke Memory Dysfunction in Old Mice
Zahra Shabani, Peipei Pan, Qifeng Li, Zhanqiang Wang, Kun Leng, Shalika Sangras, Kang Huo, Alka Yadav, Calvin Wang, Joshua Shi, Rich Liang, Gregory A. Chinn, Nikos Kyritsis, Adam R. Ferguson, Judith Hellman, Hua Su
This study shows that old mice experience long-term memory issues after stroke due to increased synapse removal by inflammatory cells, which can be mitigated by activating 7-nAchRs.
Cell & Bioscience · Aug 28, 2026Peer-reviewedNeuroscience