Divergent CRD-Dependent Mechanisms Govern RAS Isoform-Selective Recruitment of CRAF and ARAF
Shrhea Banerjee, Sravani Malasani, Shriti Banerjee, Maria Celeste Lopez Vasquez, Shane McSorley, Zhihong Wang
This study identifies divergent CRD-dependent mechanisms by which RAS isoforms selectively recruit CRAF and ARAF, revealing how the CRD modulates RAS affinity and RAF activation.
Protein Science · Jul 9, 2026Peer-reviewedBiochemistry