Zhihong Wang

This study identifies kinetic differences in RAS-BRAF engagement between KRAS and NRAS, showing how oncogenic mutations and inhibitor sensitivity are influenced by these dynamics.

This study identifies new TGM2-catalyzed histaminylation marks on core histones in cancer cells and reveals their crosstalk with γH2AX formation in DNA damage responses.

This study identifies divergent CRD-dependent mechanisms by which RAS isoforms selectively recruit CRAF and ARAF, revealing how the CRD modulates RAS affinity and RAF activation.

This study investigates Braftide's dual effect on RAF dimer disruption and CDC37-client kinase interaction, showing proteasomal degradation and therapeutic potential.

This study investigates 3D chromatin structure changes in MLLr AML using gene-edited samples, revealing specific alterations in chromatin accessibility, compartments, TADs, and loops that impact gene expression and leukemia development.