Alzheimer-related pathogenesis is dependent on neuronal receptor PTPσ.
Yuanzheng Gu, Yaoling Shu, Angela W. Corona, Kui Xu, Allen F. Yi, Shannon Chen, Man Luo, Michel L. Tremblay, Randy J. Nelson, Gary E. Landreth, Jerry Silver, Yingjie Shen
This study identifies PTPσ as a critical regulator of Alzheimer-related pathologies by modulating APP proteolytic metabolism and downstream pathogenic processes.
bioRxiv · Apr 4, 2024 · PreprintNeuroscience