Targeting matrix metalloproteinase-14 disrupts DNA repair and reduces viability in adrenocortical carcinoma
Changxian Shen, Liudmila V. Popova, Daniel M. Chopyk, Lindsey Hartshorn, Zhongguang Li, Yaoling Shu, Caleb Araujo, Shivam Priya, Varsha Thakur, John E. Phay, Barbra S. Miller, Barbara Bedogni, Haichang Li, Priya H. Dedhia
This study shows MMP-14 is critical for ACC cell survival and DNA repair, and its inhibition reduces viability and impairs repair mechanisms.
bioRxiv · Jan 7, 2026 · PreprintCancer Biology