Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive
Daniel R. Hochbaum, Alexandra C. Dubinsky, Hannah C Farnsworth, Lauren Hulshof, Giona Kleinberg, Amanda Urke, Wengang Wang, Richard Hakim, Keiramarie Robertson, Canaria Park, Alyssa Solberg, Yechan Yang, Caroline Baynard, Naeem M. Nadaf, Celia C. Beron, , Bernardo Luis Sabatini
This study shows thyroid hormone remodels cortical circuits in adult mice, linking metabolic state to exploratory behavior through transcriptional changes in neurons and glia.
bioRxiv · Aug 10, 2023 · PreprintNeuroscience