Naeem M. Nadaf

The paper maps a mesoscale molecular architecture of the human striatum across cell types and age, revealing zonal differences in gene expression and aging effects.

The paper introduces Synapse-seq, a method to link transcriptomes to synaptic architecture by using protein-guided RNA barcoding, revealing new insights into neural connectivity and cell type-specific dendritic structures.

This study identifies IL13 as a survival factor for Hodgkin lymphoma cells by analyzing the tumor microenvironment with spatial and single-cell resolution.

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

Cassini enables cost-effective, multiplexed profiling of mRNA and protein in tissue samples with high sensitivity and speed.

This study uses spatial transcriptomics and single-nucleus RNA-seq to analyze remyelination dynamics, identifying an interferon-responsive glial state that coordinates immune infiltration and oligodendrocyte differentiation.

The paper identifies a Purkinje cell to parabrachial nucleus pathway that enables cerebellar influence over forebrain regions involved in nonmotor functions, distinct from the traditional deep cerebellar nuclei pathway.

This study shows thyroid hormone remodels cortical circuits in adult mice, linking metabolic state to exploratory behavior through transcriptional changes in neurons and glia.

The paper identifies a transient hyperactive neuronal state in early Alzheimer's disease using single-nucleus transcriptomics from living patients.

The paper maps antisense oligonucleotide activity in the brain using single-cell transcriptomics in mice and macaques, showing widespread target suppression across cell types with varying durations.

Slide-tags enables spatial localization of single nuclei for multi-modal spatial genomics, achieving high-resolution mapping and multiomic profiling in various tissues.

Whole-brain snRNA-seq paired with Slide-seq assigns cell types to each mouse neuroanatomical structure; most clusters need at least three markers to be defined uniquely.

The paper shows enzymatic dissociation causes gene expression changes in microglia and proposes a protocol to reduce these artifacts in scRNA-seq.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

The paper creates a comprehensive atlas of mouse primary motor cortex cell types using integrated transcriptomic and epigenomic data from over 600,000 samples.

The paper identifies ten distinct midbrain dopaminergic neuron populations in Parkinson's disease, highlighting an AGTR1-expressing subtype vulnerable to degeneration and associated with PD risk genes.

The paper identifies candelabrum cells as abundant, GABAergic interneurons in the cerebellar cortex with distinct molecular properties and a unique role in circuit function.

This study creates a transcriptomic atlas of the mouse cerebellum, identifying regional specializations and novel cell types, including two distinct molecular layer interneuron subtypes.