Bernardo Luis Sabatini

SPOUT is an open-source platform for studying decision-making in mice by integrating neural recording and manipulation with behavioral tasks.

This study develops a behavioral platform to study decision making in marmosets and finds that reward predictability influences behavioral states and error correction during task performance.

This study shows that striatal activity encodes short-term action-outcome memories to guide future decisions in mice.

The paper develops a model of compartment-specific spike-timing dependent plasticity (STDP) that explains the enrichment of retinotopically displaced inputs on distal dendrites in visual cortex.

This paper identifies Kv6.4 as a PV neuron-specific Kv channel subunit that modulates action potential waveform and synaptic plasticity during high-frequency firing.

This paper introduces LifeCamp, a high-speed calcium lifetime sensor developed using RALISED, enabling accurate measurement of baseline and transient calcium levels in neurons.

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

The paper shows that hunger increases exploration by modulating dopamine signaling in the tail of the striatum via AgRP neurons.

The paper develops FLIPR, a system for absolute fluorescence lifetime measurement in mice, revealing spatial and temporal variations in dopamine signaling.

The paper introduces face-rhythm, an unsupervised pipeline for analyzing rodent facial movements, and shows it can decode task variables and cortical activity.

The paper shows that synaptic sign switching mediates dopamine updates and contributes to reinforcement learning by altering synaptic signs and weights in EP-LHb synapses.

The paper shows that striatal activity is required for trial-to-trial learning improvements but not for memory recall.

The paper introduces ATLAS, an anterograde transsynaptic tracer based on an antibody-like protein, which enables non-toxic, synaptic, and activity-dependent circuit tracing in vivo and in dissociated cultures.

This study shows dopamine reward transients rapidly recalibrate movement timing through one-shot updates to behavioral vigor, revealing a mechanism linking dopamine's roles in reinforcement, motivation, and movement.

This study investigates the role of GABA/glutamate cotransmitting neurons in the entopeduncular nucleus during a probabilistic switching task, finding they are engaged but their manipulation does not alter behavior.

This study identifies and maps glioma-innervating neurons (GINs) using rabies virus tracing and reveals their distinct electrophysiological properties and integration into brain networks.

The paper identifies two distinct electrophysiological and molecular phenotypes of pallidocortical neurons projecting to motor and non-motor cortical regions, revealing a closed-loop circuit between the GPe and cortex.

This study shows that frontal cortical circuits in mice continue to mature beyond sexual maturity, affecting decision-making behaviors with age.

The paper shows that blue light can falsely trigger dopamine release measurements using RdLight1, questioning previous findings on cholinergic interneurons' role in dopamine release.

The paper develops a Cre-dependent reporter mouse, FL-AK, for quantitative imaging of PKA activity dynamics in vivo and ex vivo.

The paper shows that cortical reactivations predict future sensory responses and representational drift in mice.

This study shows thyroid hormone remodels cortical circuits in adult mice, linking metabolic state to exploratory behavior through transcriptional changes in neurons and glia.

The paper introduces SBARRO, a method that maps synaptic connections and RNA expression in neurons using barcoded rabies virus and single-cell RNA sequencing, revealing cell-type-specific synaptic networks in mouse brain cells.

This study constructs a single-cell atlas of the murine ovary by analyzing >34,000 cells across the estrous cycle to characterize cell state dynamics and transcriptional changes.

The paper investigates how dopamine and acetylcholine interact in the striatum during decision making, revealing their dynamic relationship and the role of local and long-range inputs.

The paper models mouse decision-making in a probabilistic task, finding that behavior can be described by equivalent models with parameters capturing stickiness and stochasticity.

The paper shows that specific dendritic branches in cortical layer 2/3 pyramidal cells fail to evoke calcium influx from bAPs due to branch-specific properties, despite having functional VGCCs.

The paper demonstrates co-packaging of glutamate and GABA in individual synaptic vesicles of EP Sst+ neurons using a combined electrophysiology, optogenetics, and computational modeling approach.

The paper identifies a brain-wide circuit that modulates micturition behavior based on social and sensory contexts in mice.

This paper presents a method to rapidly isolate synaptic vesicles and profile their metabolites, revealing that only glutamate and GABA are detectable polar metabolites in SVs.