A Hypothalamic Pathway for Energy Conservation
Amelia Douglass, Nicole Lynch, Matías Andina…·Natalia Machado
This study identifies a hypothalamic pathway involving ARCAgRP neurons and the MnPO that triggers energy conservation during fasting.
Author
Beth Israel Deaconess Medical CenterORCID 0000-0003-1787-6925Unclaimed ORCID profile · follow to get notified of new preprints
11 papers
Recent·Most cited
Amelia Douglass, Nicole Lynch, Matías Andina…·Natalia Machado
This study identifies a hypothalamic pathway involving ARCAgRP neurons and the MnPO that triggers energy conservation during fasting.
Nagasuryaprasad Kotikalapudi, Deepti Ramachandran, Evelyn Y Zhou…·Alexander S. Banks
This study identifies GDF3 as an endogenous inhibitor of the ActE-ALK7 pathway in adipocytes, showing its role in metabolic diseases like MASLD/MASH and suggesting GDF3 inhibition as a therapeutic target.
Daniel E. Vieira, Emily M. Langmeyer, Marissa D. Cortopassi…·Alexander S. Banks
This paper introduces a non-invasive method to measure oral-cecal transit time in mice by tracking microbial oxidation of 13C-mannitol to 13CO2 using spectroscopy and calorimetry.
Evelyn Y Zhou, Corey D. Holman, Michelle Lee…·Alexander S. Banks
This study uses continuous glucose monitoring and indirect calorimetry in mice to assess metabolic responses to various physiological stressors, revealing dynamic changes in glycemia and energy expenditure.
Aleksei E. Mikhalchenko, June K. Corrigan, Yuchen He…·Vadim N. Gladyshev
This study investigates the thermogenic potential of naked mole-rat brown adipose tissue and its ability to maintain body temperature in cold, finding that NMRs can initiate non-shivering thermogenesis but cannot sustain it due to heat loss and substrate limitations.
Julian M. Roessler, Matthew Alkire, Nathan T Nigrin…·Siniša Hrvatin
The paper identifies a preoptic neurocircuit that modulates metabolic flexibility by shifting fuel use from glucose to fatty acids through insulin resistance in skeletal muscle.
Christopher Auger, Hiroshi Nishida, Bo Yuan…·Shingo Kajimura
SLC25A45 is the inner mitochondrial membrane transporter for trimethyllysine required for de novo carnitine biosynthesis, enabling metabolic fuel switching to fatty acid oxidation during cold exposure and semaglutide treatment.
Neeraj K. Lal, Phuong Le, Samarth Aggarwal…·Ye Li
The paper identifies the xiphoid nucleus in the midline thalamus as a key region controlling cold-induced food seeking through neural activity and connectivity studies in mice.
Daniel R. Hochbaum, Alexandra C. Dubinsky, Hannah C Farnsworth…·Bernardo Luis Sabatini
This study shows thyroid hormone remodels cortical circuits in adult mice, linking metabolic state to exploratory behavior through transcriptional changes in neurons and glia.
Claire Bryant, Amy Webb, Alexander S. Banks…·Shipra Agrawal
The paper identifies distinct PPARγ mRNA variants in podocytes compared to adipose tissue, highlighting differences in splicing patterns and regulatory mechanisms.
Amir I. Mina, Raymond A. LeClair, Katherine B. LeClair…·Alexander S. Banks
CalR is a web-based tool for analyzing indirect calorimetry data, offering statistical analysis, visualization, and standardized output to improve reproducibility and efficiency in metabolic experiments.