Trim-Away degrades lysine-less substrates without requiring ligase autoubiquitination
L. Kiss, Tyler Rhinesmith, Claire F. Dickson, Jonas Weidenhausen, Shannon Smyly, Jakub Lupták, Ji‐Chun Yang, Sarah Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C. James
This study shows TRIM21 can degrade lysine-less substrates without autoubiquitination, revealing a non-canonical ubiquitination mechanism for Trim-Away.
bioRxiv · Jun 29, 2022 · PreprintMolecular Biology