Irmgard Sinning

The paper identifies small-molecule activators of the Staphylococcus aureus ClpC/ClpP protease through high-throughput screening and characterizes their binding sites.

This study identifies potent DNMT2 inhibitors through DNA-encoded library screening, revealing a cryptic allosteric binding site and optimizing an inhibitor with low nanomolar affinity.

This study shows that the N-terminus of Wnt proteins determines their secretion and signaling properties, with Wnt11's N-terminus enabling Evi/Wls-independent secretion and Frizzled 6 activation.

The paper reports cryo-EM structures of aberrant spliceosome intermediates in S. pombe, revealing how a helicase-protein pair maintains catalytic dormancy and facilitates disassembly.

The paper reveals how human NatA and MAP1/MAP2 coordinate co-translational N-terminal modifications on the ribosome through distinct protein assemblies.

This study identifies the interaction between Pla1 and Red1 in the MTREC complex and shows its role in polyadenylation of CUTs and heterochromatic island assembly.

This study shows Lem2, an inner nuclear membrane protein in S. pombe, recruits exosome co-factors to the nuclear periphery to regulate RNA degradation and coordinate transcripts during the mitosis-to-meiosis switch.

This study shows TRIM21 can degrade lysine-less substrates without autoubiquitination, revealing a non-canonical ubiquitination mechanism for Trim-Away.

This study identifies how complexin suppresses spontaneous exocytosis by binding the membrane-proximal regions of VAMP2 and SNAP25.