Leo C. James

This study shows that the central pore of HIV-1 capsomers, mediated by R18 and K25 rings, is critical for capsid stability and post-entry events, with the N21K mutation compensating for R18 loss.

This study uses molecular simulations to show that lenacapavir disrupts HIV-1 capsid assembly by altering hexamer/pentamer ratios and impairing RNA encapsidation.

This study shows that cyclophilin A inhibits HIV-1 nuclear entry in mutants by reducing capsid elasticity, which is reversed by suppressor mutations.

This study shows that antibodies alone can limit Salmonella infection, but their effectiveness is enhanced by complement and macrophages.

This study identifies HOIP and linear ubiquitin chains as critical for TRIM21-mediated ADIN by recruiting VCP, enhancing virus neutralization.

This study shows TRIM21 can degrade lysine-less substrates without autoubiquitination, revealing a non-canonical ubiquitination mechanism for Trim-Away.

The paper investigates whether tau assemblies behave like independently acting prion-like particles in mouse neural tissue and finds that seeding behavior only occurs at supra-physiological concentrations.

This study reveals how substrate-induced clustering activates TRIM21's ubiquitination activity for antiviral responses and protein degradation, introducing optogenetically controllable TRIM21-nanobody chimeras.

This study shows SARS-CoV-2 infects choroid plexus epithelial cells in brain organoids, disrupts the blood-CSF barrier, and may contribute to neurological complications.

This paper introduces a method combining fluorescence microscopy and statistical modeling to accurately determine the stoichiometry of bio-molecular complexes.