Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease
Vinicius M. Fava, Yong Zhong Xu, Guillaume Lettre, Nguyen Van Thuc, Marianna Orlova, Vu Hong Thai, Shao Tao, Nathalie Croteau, Mohamed A. Eldeeb, Emma J. MacDougall, Geison Cambri, Ramanuj Lahiri, Linda B. Adams, Edward A. Fon, Jean‐François Trempe, , Erwin Schurr
The paper identifies rare variants in PRKN and LRRK2 associated with leprosy type-1 reactions and finds overlap with Parkinson’s disease pathogenic mechanisms.
Proceedings of the National Academy of Sciences · Jul 15, 2019Peer-reviewedGenetics