Erwin Schurr

The paper shows STING dampens the unfolded protein response to allow self-antigen presentation on MHC-I during inflammation, linking it to immune regulation in Parkinson's disease.

The paper shows LRRK2 mutations impair NCOA4 trafficking during iron overload, causing ferroptotic cell death in macrophages.

This study shows that continuous ART causes senescence-like changes in alveolar macrophages, increasing inflammation and impairing immune responses to SARS-CoV-2.

This study identifies genetic overlaps between leprosy type-1 reactions and neurodegenerative diseases, revealing shared and antagonistic pleiotropic effects through specific gene variants.

The paper compares the neutrophil response to Mycobacterium tuberculosis infection between HIV+ individuals with and without TB history, finding distinct gene expression and NETosis patterns in those without TB.

The paper investigates how HIV and antiretroviral therapy affect the transcriptional and epigenetic response of alveolar macrophages to Mycobacterium tuberculosis.

This study uses cell-free DNA methylation profiling in plasma to identify organ-specific injury and predict COVID-19 severity in hospitalized patients.

This paper introduces ggmix, a penalized linear mixed model for SNP selection and population structure adjustment in high-dimensional genetic prediction models, showing improved accuracy and parsimony over existing methods.

The paper identifies rare variants in PRKN and LRRK2 associated with leprosy type-1 reactions and finds overlap with Parkinson’s disease pathogenic mechanisms.