This study identifies genetic overlaps between leprosy type-1 reactions and neurodegenerative diseases, revealing shared and antagonistic pleiotropic effects through specific gene variants.

Scientific Reports · Dec 22, 2025Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations

Jocelyn Quistrebert, Marianna Orlova, Gaspard Kerner, Le Thi Ton, Nguyễn Trong Luong, Nguyễn Thanh Danh, Quentin B. Vincent, Fabienne Jabot‐Hanin, Yoann Seeleuthner, Jacinta C. Bustamante, Stéphanie Boisson‐Dupuis, Nguyễn Thu Hương, Nguyen Ngoc Ba, Jean‐Laurent Casanova, Christophe Delacourt, , Aurélie Cobat

PLoS Genetics · Mar 4, 2021Peer-reviewedGenetic & Genomic Medicine

Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease

Vinicius M. Fava, Yong Zhong Xu, Guillaume Lettre, Nguyen Van Thuc, Marianna Orlova, Vu Hong Thai, Shao Tao, Nathalie Croteau, Mohamed A. Eldeeb, Emma J. MacDougall, Geison Cambri, Ramanuj Lahiri, Linda B. Adams, Edward A. Fon, Jean‐François Trempe, , Erwin Schurr

The paper identifies rare variants in PRKN and LRRK2 associated with leprosy type-1 reactions and finds overlap with Parkinson’s disease pathogenic mechanisms.

Proceedings of the National Academy of Sciences · Jul 15, 2019Peer-reviewedGenetics