Inferring Telomerase Enzymatic Activity from Expression Data
Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W.K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew T. Ludlow, Siyuan Zheng
The paper introduces a method to estimate telomerase enzymatic activity using a 13-gene expression signature and validates it across multiple datasets, finding a strong correlation with cancer stemness.
Nature Communications · Jan 8, 2021Peer-reviewedBioinformatics