Jonathan Gelfond

Deciphering the Timing and Impact of Life-extending Interventions: Temporal Efficacy Profiler Distinguishes Early, Midlife, and Senescence Phase Efficacies

The paper introduces a tool to estimate age-specific treatment effects on mortality hazards, applied to mouse data showing varying efficacy of life-extending interventions across lifespan stages.

The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride.

The paper reanalyzes ITP data using the Gehan test, identifying 5 compounds that extend mouse lifespan, missed by the log-rank test.

Inferring Telomerase Enzymatic Activity from Expression Data

The paper introduces a method to estimate telomerase enzymatic activity using a 13-gene expression signature and validates it across multiple datasets, finding a strong correlation with cancer stemness.