Juechen Yang

Multi-Agent Orchestration for Knowledge Extraction and Retrieval: AI Expert System for GPCRs

GPCR-Nexus integrates structured databases and literature using a multi-agent AI system to provide accurate, traceable knowledge about GPCRs.

Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS)

This study uses SEC-ICP-MS to assess copper allocation to cytochrome c oxidase and identifies key transporters involved in mitochondrial copper trafficking.

PRPS activity tunes redox homeostasis in Myc-driven lymphoma

This study identifies PRPS2 as a key regulator of redox homeostasis in Myc-driven lymphomas, showing that its inactivation causes reductive stress and cell death.

Accelerating Drug Discovery and Repurposingby Combining Transcriptional Signature Connectivity with Docking

This paper introduces ceSAR, a method combining docking and transcriptional signature connectivity to improve drug discovery and repurposing by reducing false positives and computational costs.

Inferring Telomerase Enzymatic Activity from Expression Data

The paper introduces a method to estimate telomerase enzymatic activity using a 13-gene expression signature and validates it across multiple datasets, finding a strong correlation with cancer stemness.

PCAT: An integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models

PCAT is a portal for pediatric cancer PDX models and associated genomic data, providing clinical, molecular, and preclinical testing information for 324 models and 79 therapeutic agents.