Andrew T. Ludlow

This study examines dermal endothelial cells from people with type 2 diabetes, finding they have altered migratory, angiogenic, and gene expression profiles compared to healthy cells.

This study examines how acute endurance exercise affects alternative splicing in skeletal muscle using short-read and long-read RNA sequencing, identifying significant changes in RNA-binding proteins and isoform expression.

This study investigates the relationship between relative rDNA copy number and resistance training-induced skeletal muscle hypertrophy, finding no significant association.

The paper introduces a method to estimate telomerase enzymatic activity using a 13-gene expression signature and validates it across multiple datasets, finding a strong correlation with cancer stemness.

This paper introduces a ddPCR method to measure mtDNA copy number at single-cell resolution, showing its ability to detect subtle changes in mtDNA content across aging and cancer.

The paper demonstrates that human telomerase holoenzymes have fast- and slow-acting catalytic sites that become inactive after two rounds of catalysis, and can be reactivated by intracellular factors.