The Sez6 family inhibits complement at the level of the C3 convertase.
Wen Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny Margaret Gunnersen, Harris A. Gelbard, Jennetta W. Hammond
This study shows that Sez6 family members inhibit C3 convertase activity in both classical and alternative complement pathways.
bioRxiv · Sep 11, 2020 · PreprintNeuroscience