Priyanka Saminathan

LPC 18:2-Driven Apoptosis In Neutrophils Is Non-Inflammatory and Lipid Raft Dependent

This study compares the effects of LPC 18:2 and LPC 16:0 on neutrophil apoptosis, showing LPC 18:2 induces non-inflammatory, lipid raft-dependent apoptosis while LPC 16:0 causes inflammatory pyroptosis.

Deoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes

This study shows DGUOK deficiency disrupts purine metabolism, leading to lipid accumulation and innate immune activation in hepatocytes, independent of mtDNA depletion.

Unmasking Early Microglial Remodeling in an Alzheimer's Disease Mouse Model

The paper quantifies early microglial structural changes in 5xFAD mice before amyloid plaques, revealing sex-specific differences and a link between morphology and phagolysosomal activity.

The Sez6 family inhibits complement at the level of the C3 convertase.

This study shows that Sez6 family members inhibit C3 convertase activity in both classical and alternative complement pathways.

Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis

This study investigates complement-dependent synapse loss and microgliosis in EAE mice, finding that C3 knockout reduces synapse loss and microglial activation.

The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders

This study shows that URMC-099 prevents surgery-induced microglial activation and cognitive decline in a mouse model of PND without affecting bone healing.