Jennetta W. Hammond

This study characterizes Sez6l2 knockout mice, showing behavioral and synaptic deficits, and compares them to Sez6 triple knockout mice, highlighting SEZ6L2's non-redundant role in brain function.

This study shows that genetic background affects SEZ6L2 autoimmunity, with SJL mice showing stronger immune responses and neurological dysfunction compared to C57BL/6 mice.

This study shows that Sez6L2 autoimmunity in mice causes cerebellar ataxia, with antibodies and T cells targeting Sez6L2 leading to mobility impairments and brain inflammation.

This study shows that Sez6 family members inhibit C3 convertase activity in both classical and alternative complement pathways.

This study investigates complement-dependent synapse loss and microgliosis in EAE mice, finding that C3 knockout reduces synapse loss and microglial activation.