Author

Shaopeng Zeng

Johns Hopkins University

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Genetics· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Charles NewcombiD· 1 shared Christina A. CastellaniiD· 1 shared Dan E. ArkingiD· 1 shared Jiaqi XieiD· 1 shared Phyo Wei WiniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperGenetics

Charles NewcombORCID

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1 paper

Recent·Most cited

Transcriptomic analysis of cells following decreased mitochondrial DNA-copy number reveals compensatory mechanisms in mitochondrial DNA replication and cellular energetics

Jiaqi Xie, Phyo Wei Win, Charles Newcomb, Shaopeng Zeng, Christina A. Castellani, Dan E. Arking

The paper investigates transcriptomic and methylomic changes in HEK 293T cells with reduced mtDNA copy number, revealing compensatory mechanisms in mitochondrial replication and metabolic pathways.

Experimental Cell Research · Feb 25, 2026Peer-reviewedGenetics