Jiaqi Xie

The paper investigates transcriptomic and methylomic changes in HEK 293T cells with reduced mtDNA copy number, revealing compensatory mechanisms in mitochondrial replication and metabolic pathways.

This study shows that deleterious mitochondrial DNA mutations increase over time and are associated with higher mortality risk, suggesting positive selection rather than genetic drift.

The paper identifies genome-wide mutational dependencies in Mycobacterium tuberculosis evolution, showing how mutations interact to confer antibiotic resistance and detect environmental pressures.