Christina A. Castellani

The paper investigates transcriptomic and methylomic changes in HEK 293T cells with reduced mtDNA copy number, revealing compensatory mechanisms in mitochondrial replication and metabolic pathways.

This study examines how exposure to recombinant FABP3 affects endothelial cell transcriptomics, identifying key genes and pathways involved in immune response and angiogenesis.

EpigeneticAgePipeline is an R package that estimates various epigenetic age metrics from methylation microarrays, offering quality control, preprocessing, and visualization tools.

This study shows that reducing mitochondrial DNA copy number in human cells changes nuclear DNA methylation and gene expression, revealing pathways linked to disease.

This study identifies 100 loci associated with mitochondrial DNA copy number and finds causal links between mitochondrial function and mortality.

This study identifies CpGs associated with mtDNA-CN and shows they influence disease-related phenotypes through nDNA methylation and gene expression changes.

This study investigates the association between mitochondrial DNA copy number and risk of atrial fibrillation in three cohorts, finding an inverse relationship after adjustment for traditional risk factors.

The paper investigates hippocampal gene expression changes in a mouse model of FASD following prenatal alcohol exposure and maternal separation, identifying altered RNA processing as a potential mechanism for anxiety-like behavior.

This study evaluates methods for estimating mitochondrial DNA copy number, finding that whole genome sequencing provides more accurate associations with known correlates than qPCR or microarray platforms.