Intranuclear polyglycine aggregation drives neurodegeneration through epigenetic repression of chromatin accessibility and transcription
Yangye Lian, Shaoping Zhong, Jiaxin Huang, Luyao Huang, Yuzhe Li, Jingzhen Liang, Xin Wang, Jing Ding
This study shows intranuclear polyG aggregates cause more severe neurodegeneration than cytoplasmic ones by repressing chromatin accessibility and transcription through epigenetic mechanisms.
bioRxiv · May 14, 2026 · PreprintNeuroscience