Multivalent interaction induces phase separation and formation of more toxic aggregates of α-syn in a yeast model of Parkinsons disease
Rajeev Jain, Sharavanakkumar SK, Krishnananda Chattopadhyay
This study investigates how multivalent interactions affect α-synuclein phase separation and toxicity in a yeast model of Parkinson's disease, identifying two distinct aggregation pathways with different fibril characteristics and toxicities.
Protein Science · Aug 15, 2025Peer-reviewedBiophysics