Krishnananda Chattopadhyay

Crowder induced conformational fluctuations modulate the phase separation of yeast SUP35 NM domain

This study shows that crowder shape affects Sup35NM conformation and phase separation, with rod-like crowders promoting phase separation while spherical ones do not.

Heterotypic FG-Nup98-tau condensates form nested assemblies through stoichiometry-dependent phase transitions

This study investigates how FG-Nup98 and tau form heterotypic condensates through phase transitions, revealing their potential role in disrupting nuclear pore permeability.

Multivalent interaction induces phase separation and formation of more toxic aggregates of α-syn in a yeast model of Parkinsons disease

This study investigates how multivalent interactions affect α-synuclein phase separation and toxicity in a yeast model of Parkinson's disease, identifying two distinct aggregation pathways with different fibril characteristics and toxicities.

Spatio-temporal regulation of ligand trafficking and TLR9 activation involves PIEZO1 mechanosensing in human plasmacytoid dendritic cells

This study identifies PIEZO1 mechanosensing as a key regulator of ligand-specific TLR9 signaling in human pDCs, showing that CpGA induces IFN production via membrane tension and PIEZO1 activation, while CpGB does not.

Heterotypic Protein Interactions Modulate the Condensate Dynamics and Aggregation of α-Synuclein

This study investigates how heterotypic protein interactions affect α-synuclein condensate dynamics and aggregation, showing that multivalent electrostatic interactions drive co-condensation and promote amyloid fibril formation.

Mapping DHPS Evolvability: Identification of Novel Evolutionarily Critical Sub-Structure through Evolutionary and Structural Analyses of DHPS

The paper identifies a critical substructure in DHPS through evolutionary and structural analyses, suggesting it as a target to constrain evolvability and disrupt antibiotic resistance.

Mechanism of host cell invasion by Leishmania through KMP-11 mediated cholesterol-transport and membrane phase transition

This paper identifies KMP-11 as a key Leishmania protein that mediates host cell invasion via cholesterol transport and membrane phase transition.

Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy

This paper designs a peptide-loaded porous organic polymer that undergoes a conformational switch in cancer cells, triggering pyroptosis via membrane pore formation.

Amyloid Beta Oligomers Accelerate ATP-Dependent Phase Separation of Ago2 to RNA Processing Bodies

This study shows amyloid beta oligomers enhance Ago2 phase separation to RNA processing bodies by promoting miRNA-mRNA targeting, while HuR counteracts this effect.

IMMUND: an Early Stage Diagnostic and Therapeutic Frame for Neurodegenerative Diseases and Multiple Sclerosis based on Immunological Markers

The paper proposes a framework to identify diagnostic and therapeutic autoantibodies for neurodegenerative diseases and multiple sclerosis using statistical and structural analysis.