Gβγ dually regulates the M current via increased channel surface expression and PIP2 sensitivity
Boris Shalomov, Iiulia Papa-Dmitrieva, Tal Keren Raifman, SHARON WEISS, Flavia Martino, Adi Gali-Sayag, Joel A. Hirsch, Maurizio Taglialatela, Vincenzo Barrese, Kerstin Zühlke, Enno Klußmann, Iain Andrew Greenwood, Ilana Lotan, Nathan Dascal
This study shows Gβγ enhances M-current by increasing channel surface expression and stabilizing PIP2 coupling in Xenopus laevis oocytes.
bioRxiv · Sep 21, 2026 · PreprintPhysiology