Author

Boris Shalomov

Tel Aviv UniversityORCID 0000-0002-1322-4906Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:electrophysiology· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Nathan DascaliD· 4 shared Haritha P. ReddyiD· 3 shared Anna Stary‐WeinzingeriD· 2 shared Daniel YakubovichiD· 2 shared Enno KlußmanniD· 2 shared Galit TabakiD· 2 shared Joel A. HirschiD· 2 shared Kerstin Zühlke· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

Nathan DascalORCID

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4 papers

Recent·Most cited

Gβγ dually regulates the M current via increased channel surface expression and PIP2 sensitivity

Boris Shalomov, Iiulia Papa-Dmitrieva, Tal Keren Raifman, SHARON WEISS, Flavia Martino, Adi Gali-Sayag, Joel A. Hirsch, Maurizio Taglialatela, Vincenzo Barrese, Kerstin Zühlke, Enno Klußmann, Iain Andrew Greenwood, Ilana Lotan, Nathan Dascal

This study shows Gβγ enhances M-current by increasing channel surface expression and stabilizing PIP2 coupling in Xenopus laevis oocytes.

bioRxiv · Sep 21, 2026 · PreprintPhysiology

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels

Reem Handklo‐Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Theres Friesacher, Galit Tabak, Vladimir Tsemakhovich, Haritha P. Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zühlke, CARMEN W. DESSAUER, Enno Klußmann, Yoni Haitin, , Nathan Dascal

The paper shows Gβγ interacts with GIRK2 and GIRK1/2 channels with affinities in the microM range, with GIRK1/2 having higher apparent affinity due to a unique Gβγ docking site.

Nature Communications · Nov 24, 2025Peer-reviewedPhysiology

Ethosuximide: subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels

Boris Shalomov, Theres Friesacher, Daniel Yakubovich, John Carlo Combista, Haritha P. Reddy, Shoham Dabbah, Harald Bernsteiner, Eva‐Maria Zangerl‐Plessl, Anna Stary‐Weinzinger, Nathan Dascal

This study identifies ethosuximide as a subunit-selective, Gβγ-dependent blocker of GIRK channels, revealing its mechanism of action and potential as a therapeutic tool.

British Journal of Pharmacology · Jan 15, 2025Peer-reviewedPharmacology & Toxicology

G protein-coupled potassium channels implicated in mouse and cellular models of GNB1 Encephalopathy

Sophie Colombo, Sabrina Petri, Boris Shalomov, Haritha P. Reddy, Galit Tabak, Ryan S. Dhindsa, Sahar Gelfman, Sasa Teng, Daniel K. Krizay, Elizabeth E. Rafikian, Amal Kanti Bera, Mu Yang, Michael J. Boland, Yueqing Peng, Wayne N. Frankel, , David B. Goldstein

This study identifies GNB1 mutations causing neurodevelopmental disorder and shows ethosuximide effectively treats symptoms in mouse and cellular models.

bioRxiv · Jul 9, 2019 · PreprintNeuroscience