Maurizio Taglialatela

This study shows Gβγ enhances M-current by increasing channel surface expression and stabilizing PIP2 coupling in Xenopus laevis oocytes.

This study investigates how gain-of-function variants in the Kv7.2 channel's activation gate stabilize a partially open conformation, enabling K+ permeation and linking it to neurodevelopmental disorders.

This study investigates the two-step voltage-sensor activation mechanism of the KV7.4 channel and shows how a deafness mutation disrupts this process.

This study shows that KCNQ2 loss-of-function causes early hyperexcitability and network remodeling in human neurons, with biphasic changes in function, gene expression, and structure.

This study identifies two KCNQ2 variants causing developmental encephalopathies by constitutively opening the Kv7.2 pore activation gate, leading to gain-of-function effects.

This study identifies type I TARPs as regulators of Kv7.2 potassium channels and shows their role in modulating neuronal excitability and seizure susceptibility.