Author

Shaun M Purcell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Patrick F Sullivan· 3 shared Benjamin M Neale· 2 shared Steven A McCarroll· 2 shared A. Ercument Cicek· 1 shared Aarno Palotie· 1 shared Aaron Topol· 1 shared Alex Bloemendal· 1 shared Alexander GuseviD· 1 shared

Activity by Year

2014-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetics

Patrick F Sullivan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

Andrea Ganna, Giulio Genovese, Daniel P Howrigan, Andrea Byrnes, Mitja Kurki, Seyedeh M Zekavat, Christopher W Whelan, Robert E Handsaker, Mart Kals, Alex Bloemendal, Jonathan M Bloom, Jacqueline I Goldstein, Timothy Poterba, Cotton Seed, Michel G Nivard, , Benjamin M Neale

This study finds that ultra-rare disruptive variants in highly constrained genes are associated with reduced educational attainment in the general population.

bioRxiv · Jun 7, 2016Genetics

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

Menachem Fromer, Panos Roussos, Solveig K Sieberts, Jessica S Johnson, David H Kavanagh, Thanneer M Perumal, Douglas M Ruderfer, Edwin C Oh, Aaron Topol, Hardik R Shah, Lambertus L Klei, Robin Kramer, Dalila Pinto, Zeynep H Gumus, A. Ercument Cicek, , Lara M Mangravit

The paper uses gene expression data from schizophrenia cases and controls to show that common variants at 20% of schizophrenia risk loci regulate brain gene expression, with functional impacts on neural progenitor cells and zebrafish neuroanatomy.

bioRxiv · May 9, 2016Genomics

Regulatory variants explain much more heritability than coding variants across 11 common diseases

Alexander Gusev, S Hong Lee, Benjamin M Neale, Gosia Trynka, Bjarni J Vilhjalmsson, Hilary Finucane, Han Xu, Chongzhi Zang, Stephan Ripke, Eli Stahl, n/a Schizophrenia Working Group of the PGC, n/a SWE-SCZ Consortium, Anna K Kahler, Christina M Hultman, Shaun M Purcell, , Alkes L Price

The paper shows regulatory variants explain significantly more heritability than coding variants for 11 diseases, using imputed data across 218 cell types.

bioRxiv · Apr 21, 2014 · PreprintGenetics