Han Xu

Catamers: Multi-specific therapeutics that concatenate individual warheads on a DNA scaffold via Watson-Crick interactions

This paper introduces catamers, synthetic multi-specific therapeutics assembled via Watson-Crick interactions, and demonstrates their potential to address challenges in multi-specific drug design.

Targeting cancer-associated cell surface RNAs with oligonucleotide-drug conjugates enables broad antitumor activity

This study develops CIRCmap to profile cell-surface and intracellular RNAs, identifies cancer-associated csRNAs, and demonstrates oligonucleotide-drug conjugates targeting these RNAs show broad antitumor activity.

RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma

The paper shows that activating RIG-I in macrophages enhances immunotherapy for glioblastoma by repolarizing tumor-associated macrophages and boosting anti-tumor immune responses.

Partitioning heritability by functional category using GWAS summary statistics

This paper partitions heritability across functional genomic elements using GWAS summary statistics to identify trait-specific enrichments.

Disentangling effects of colocalizing genomic annotations to functionally prioritize non-coding variants within complex trait loci

The paper develops a statistical method to distinguish causal non-coding variants from colocalizing annotations in complex trait loci, identifying independent effects in disease-associated regions.

Regulatory variants explain much more heritability than coding variants across 11 common diseases

The paper shows regulatory variants explain significantly more heritability than coding variants for 11 diseases, using imputed data across 218 cell types.