Evolutionary Origins of Molecular Programs Underlying Brain Circuitry
Z Huang, Shenglong Li, Zhenkun Zhuang, Duoyuan Chen, Xiao Du, Qun Liu, Cirong Liu, Shaojie Ma, Yidi Sun, Hongli Du, Shiping Liu, Guangyi Fan, Longqi Liu, Shijie Hao
This study reconstructs the evolutionary assembly of a conserved cortical axis across vertebrates using spatial transcriptomics and single-nucleus RNA-seq, revealing conserved molecular programs and convergent evolution in brain circuitry.
bioRxiv · Jul 1, 2026 · PreprintEvolutionary Biology